Adults who microdose report health related motivations and lower levels of anxiety and depression compared to non-microdosers.

Surveys identify diverse motivations for microdosing; respondents note reducing anxiety and depression, improving well-being, and enhancing cognitive performance as key motivations; less prominent motivations include improving physical health, and enhancing empathy, spirituality, and curiosity, ^{4, 5, 6}.

In addition to microdosing alone, growing interest has focused on a practice referred to colloquially as stacking, the combining of psilocybin microdoses with other mushrooms, e.g. Lion’s Mane, to accentuate salutary effects. A cross-sectional survey of over 4,000 microdosers found that over 50% of psilocybin microdosers combined psilocybin with a combination of niacin (vitamin-B3) and Lion’s Mane, ⁷. These microdosers report lower levels of substance use disorders, anxiety disorders, and negative emotionality, ^{8, 9}. Additionally, the flushing effects of niacin is suggested to facilitate psilocybin bioavailability and be prophylactic for abuse, ¹⁰.